The Compute Against Alzheimer's Disease project (CAAD) is a not-for-profit research initiative organized and hosted by Parabon Computation, Inc. With generous donations of idle computation from concerned citizens, the goal is to supply large-scale computational capacity to scientists investigating AD and enable them to perform groundbreaking research that would not otherwise be possible because of the scale of computation required.

The team behind the project is comprised of scientists and engineers who are passionate about their work and having it make a difference. It takes the contribution and cooperation of many people to realize a project of this magnitude and complexity. Below are just a few of the individuals who have worked to make the Compute Against Alzheimer's Disease project a success:

Ellen McRae Greytak, Ph.D.
Bioinformatics Manager
Parabon NanoLabs, Inc.

Ellen is the bioinformatics manager at Parabon NanoLabs, where she serves as lead scientist on Parabon's many bioinformatics projects. In 2011, she earned her PhD in Evolutionary Biology from Harvard, where she was the recipient of a prestigious National Science Foundation Graduate Research Fellowship. She joined Parabon in 2012 after a postdoctoral fellowship in bioinformatics at the Institute for Genome Sciences at the University of Maryland School of Medicine. As a CAAD Principal Investigator, Ellen directs the project's massive computer search for combinations of genetic biomarkers that jointly help predict increased risk for AD. She examines promising candidate combinations and helps explain their possible significance in the context of the AD literature. In her free time, Ellen is a competitive ultimate frisbee player and has competed at the national championships four times.

James O'Connor
VP Research and Development
Parabon Computation, Inc.

Jim is Vice President of Research & Development of Parabon Computation, where he is responsible for overseeing the development of novel distributed computing applications in the areas of DNA forensics, DNA nanotechnology, and molecular modeling. He is a proven technology leader and software/system architect with over twenty years of experience managing the development and operations of scalable, reliable, and secure cloud-based products and services. Jim has published his work in the areas of software engineering, database management and computer security in peer-reviewed journals and proceedings. He earned a Masters degree in Computer Science from the University of Maryland at College Park, holds the Certified Information Security Professional (CISSP) credential, and is co-inventor on a pioneering patent in the area of grid computing.

Jason Moore, Ph.D.
Professor of Genetics and of
Community and Family Medicine
Dartmouth Medical School

A Professor of many disciplines at Dartmouth College, Jason is one of the originators of the MDR algorithm employed in the searches performed by Parabon Crush. He is the Principal Investigator of an NIH Small Business Technology Transfer (STTR) project with Parabon, which aims to make Crush available as an online service. A highly published geneticist and computer scientist, with over 350 publications in journals ranging from Nature Genetics to Science, Jason serves as a scientific advisor to the CAAD investigators.

Paula and Steve
Armentrout
Co-founders
Parabon Computation, Inc.

Paula and Steve provide essential business support for all aspects of the CAAD project, from recruiting partners and sponsors to paying the electricity bills. A co-entrepreneurial couple that has worked together for over 15 years, they founded Parabon Computation in 1999 and co-founded its subsidiary, Parabon NanoLabs, in 2008, along with Drs. Michael Norton and Christopher Dwyer. Paula, an MBA and seasoned business professional, is the majordomo for CAAD, seeing to it that the many pieces of the project come together as a whole. Steve, a PhD in Computer Science who has worked and published in the fields of predictive analytics and medicine, facilitates innovative collaborations between the AD scientists and computer technologists who comprise the CAAD team. In addition to their passion for helping teams transform cutting-edge science into commercial technologies, the couple enjoys spending time together "geeking out" on a variety of subjects including robotics, ornithology and testing the boundaries of canine intelligence with their Border Terrier "Mocha."

Dmitri Klimov, Ph.D.
Associate Professor
School of Systems Biology
George Mason University

Dmitri is a biophysicist by training and received his PhD from the Department of Physics of Moscow State University. At George Mason University, his research is focused on computational studies of Alzheimer's disease. Using computer simulations, he and his colleagues examine atomic details in implicated biomolecular systems. As a Principal Investigator on the CAAD Team, Dmitri designs and directs the Aβ simulation experiments and is responsible for translating the results into actionable science. Dmitri has 20 years of experience in biomolecular simulations and has published 70 peer-reviewed scientific articles. He served as a principal investigator on several NIH funded projects, among them the molecular dynamics project included in CAAD.

Christopher Lockhart
Ph.D. Candidate
School of Systems Biology
George Mason University

Chris is a graduate student pursuing his PhD in Computational Biology under the guidance of Prof. Klimov. A talented and capable expert in molecular dynamics, he manages the execution of all Aβ simulations performed for CAAD and performs complex state-of-the-art analysis of the data. Together with Prof. Klimov, he coauthored five peer-reviewed papers, presented talks at national meetings, and has received numerous awards for research excellence. When not pulling all-nighters for the Aβ project and trying to correct inaccuracies on the order of 10-7, Chris is grateful for a chance to relax and continue working on his dissertation.

Sarah Carlson
Senior Software Engineer
Parabon Computation, Inc.

Sarah is the mastermind and software engineer responsible for Parabon Crush, the awesome genomics search software relied upon by Dr. Greytak in her CAAD project. For several years, she has continuously refined and improved Crush, making it faster, more robust and able to handle ever larger datasets. She revels at the challenge of implementing creative new software features in service to CAAD's scientific team, who, on the verge of important discoveries, have no shortage of imaginative new ideas and uses for the software. What motivates her is the knowledge that with every new Crush feature she brings CAAD scientists closer to solving the mystery of a dreaded human affliction that affects members of her own family. When not pressing the boundaries of what is possible using thousands of computers, Sarah reluctantly leaves her dogs behind and trips across the world's great mountain ranges.

Mario Bulhoes
VP of Technology
Parabon Computation, Inc.

Mario is the world-class software architect and engineer most responsible for making the Parabon Frontier Compute Platform an amazing system for performing large-scale computational science. Able to write brilliant programming code faster than most people can speak, Mario's software permeates the CAAD project, from the Frontier engine application that runs on volunteer computers to the Frontier server that manages all CAAD computational jobs. When not writing code, Mario enjoys playing guitar and taking in the great outdoors with his family.

Dabrien Murphy
Senior Solutions Architect
Parabon Computation, Inc.

A core happen-maker on the CAAD project, Dabe built and maintains the CAAD website, manages and monitors execution of the CAAD computational jobs and generally performs whatever digital manipulations are required to keep the project functioning — from patching software to rewiring servers. Known by his peers as "the smartest guy in the room," Dabe contributes to both the creative and engineering aspects of the CAAD project.